A quantitative systems pharmacology (QSP) model for predicting first-in-human (FIH) dose of bispecific antibody-drug conjugates (BsADC) based on preclinical results
Predicting efficacy of antibody drug conjugate (ADC) combined with aPD-1 x aVEGF bispecific Antibody in Platinum resistant Ovarian Cancer patients using the platform Quantitative Systems Pharmacology (QSP) model
Designing Smarter ADC Combinations: A QSP Framework for Dose Optimization
What Drives First-in-Human Dose Escalation in Oncology? A Cross-Modality Analysis of Small Molecules, Monoclonal Antibodies, ADCs, and T-Cell Engagers
ICH M15 Report for a prior regulatory approved midd analysis
QSP GUIDED MABEL ESTIMATION FOR T-CELL ENGAGERS : A CASE STUDY ON MODEL-INFORMED FIRST-IN-HUMAN DOSE SELECTION
Mechanistic modeling of efficacy and nausea of GLP-1 receptor agonist (RA) Semaglutide and dual GLP-1/GIPRA Tirzepatide in non-diabetic obese patients
Quantitative Systems Pharmacology guided MABEL estimation for T-cell Engagers (TCE): A case study to support model-informed first-in-human dose selection
Optimal therapeutic combinations for Phase 3 UC trial design- recommendations from a QSP platform model
Model-informed dose priming strategy for T cell engagers: Leveraging early clinical data to mitigate CRS
