Blog | Vantage Research

Treating obesity with diet restrictions and weight loss pills

– Anuraag Special thanks to Maithreye and Tamara Obesity is a gateway to many chronic diseases (cardiovascular diseases, diabetes, etc.) and is becoming a common problem today with 1 in 3 men having BMI greater than 30 which is documented as the official mark for being obese. In the figure below percent of obese

The second conference of the International Society for the Study of Xenobiotics (ISSX) in India – by Rukmini Kumar

Modeling in ISSX: Vantage was excited to go to the second ISSX in India to enjoy the great programming as well as we were helping with the organization of the modeling track. Plenty of modeling content was available for the participants to absorb: short course on GastroPlus from Simulations Plus, short course on a range

Odds vs. Risk

-by Rukmini Kumar In many clinical papers, probabilities are reported both as ‘risk ratios’ and ‘odds ratios’ to indicate similar things. However, they are not calculated similarly. In this blog, I’ll review the basic concepts behind these and examine how they differ with an example. Let’s start with a simple example of one event. If

Everyone Struggles with Model Validation

This blog post is a summary of a paper I enjoyed reading immensely – Verification, Validation and Confirmation of Numerical Models in the Earth Sciences, first-authored by the brilliant Naomi Oreskes. The authors’ ultimate question is ‘what makes a good model?’ They also expand on the philosophical hoops one jumps to ‘confirm’ or ‘validate’ a

Open source tools for QSP workflows using SBML, R and Python

–Prakash Packirisamy Each software tool is unique in its specialization. For QSP workflows, among the freely available software – “R” is a very good tool for handling any kind of data set obtained from biological systems; “Octave” on the other hand is good at handling Ordinary differential equations (ODEs) but may fail at handling big

Ordinary Differential Equation (ODE) based tumor models in Immunotherapy

–Kannan Thiagarajan One of the important ways in which cancer cells survive is, with their ability to turn off our own immune system by evading key immune checkpoints (such as CTLA4 and PD-1); described as one of the Hallmarks of Cancer. In this context, one of the recent approaches in fighting cancer is Immunotherapy which

American Conference of Pharmacometrics

Five of us from Vantage attended the recently held American Conference of Pharmacometrics (ACoP) held at Bellevue recently. We presented a poster on an in-house tool for parameter optimisation that Prakash and Krishna have been developing and got great feedback and suggestions from the community on improvements and features that they would like to see

Job Opening at Vantage Research: Senior Model Development Engineer

To apply via LinkedIn, click here OR Email your resume to careers@vantage-research.net Job description The Senior Engineer will lead and/or contribute to the following activities Communicate with client team to understand and define complex R&D problems, and break it down into a staged model development plan Develop mathematical models of physiological systems, run simulations

The first conference of the Society for Study of Xenobiotics, India

–Maithreye R Recently, Vikram and I attended the first conference of the Indian Society for Study of Xenobiotics, held at the JN Tata Auditorium, IISc in Bangalore. The conference is the first of its kind that I have attended and I was very impressed by the wide variety of topics presented and had a great

How Cancer Immunotherapy could use a little help from QSP Modelling

-Lakshmanan Jagannathan Everyone is familiar with the classic action movie storyline, where in, the greedy agent turns hostile and tries to destroy the system from within. He uses his knowledge of the system to his favour and allies with other rogue elements in the system. Then comes the selfless protagonist, who is usually unnoticed and